Coeliac (celiac) disease affects at least 1% of the UK population and is caused by an immune response to gluten, a protein found in the cereals wheat, barley and rye. It is associated with a broad spectrum of effects, with the worst symptoms including severe abdominal pain, diarrhoea and fatigue. Current tests for coeliac disease are relatively insensitive. In view of these difficulties, our research project is developing robust digital image analysis for the duodenal biopsy material used in diagnostic tests.